Induction of microsomal enzymes by this drug, may shorten the half-life of doxycycline for as long as 2 weeks after barbiturate therapy discontinued; observe medical reaction to doxycycline intently if equally drugs administered concurrently
pentobarbital will minimize the extent or impact of dapsone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown.
Comment: Barbiturates may well improve adverse effects, such as respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
Reserve concomitant prescribing of these drugs in people for whom other remedy solutions are insufficient. Restrict dosages and durations into the minimum expected. Watch intently for indications of respiratory despair and sedation.
pentobarbital will decrease the level or outcome of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.
Remark: Barbiturates might enhance adverse effects, including respiratory depression, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and reduce blood concentrations of TCAs.
fentanyl transdermal and pentobarbital the two boost sedation. Steer clear of or Use Alternate Drug. Limit use to sufferers for whom option cure choices are insufficient
pentobarbital will lessen the extent or outcome of ramelteon by affecting hepatic enzyme CYP2C9/ten metabolism. Minor/Importance Unfamiliar.
pentobarbital will reduce the level or influence of conjugated estrogens, vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will lower the level or influence of etoposide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Check Carefully (one)pentobarbital will minimize the level or result of mestranol by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the level or result of ambrisentan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will website lessen the level or effect of darifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lessen the extent or influence of alosetron by influencing hepatic enzyme CYP2C9/ten metabolism. Small/Significance Mysterious.